The science behind the answers
Codon doesn't let the model free-associate about your DNA. Every answer is grounded in a curated evidence base drawn from open scientific sources — and the model is instructed to reason strictly from it and never invent a locus.
ClinVar
NIH's public archive of variant–condition relationships. Source for carrier and clinical-significance calls.
PharmGKB / CPIC
The pharmacogenomics knowledge base and clinical dosing guidelines (clopidogrel, warfarin, statins, codeine).
SNPedia
Community-curated SNP encyclopedia for well-replicated traits and common variants.
How grounding works
- 1. A client-side router maps your question to the relevant loci and pulls just those genotypes from your in-browser file.
- 2. Matching evidence entries (rsid, gene, genotype→effect table, citation) are sent alongside.
- 3. The counselor must match your actual genotype to the right effect row, distinguish association from destiny, and stay non-prescriptive.
- 4. If your chip didn't test a position, it says so honestly instead of guessing.
What Codon covers today
22 curated variantsA focused, high-value set — the topics people actually search for — rather than a 20,000-row dump. Expanding over time.
Pharmacogenomics
Clopidogrel (Plavix) & CYP2C19
How you activate clopidogrel — a pro-drug your CYP2C19 enzyme must switch on.
Warfarin (Coumadin) dosing
Your CYP2C9 + VKORC1 genotype, the basis of genotype-guided warfarin dosing.
Statins & muscle pain (SLCO1B1)
Your risk of statin-induced muscle aches, driven by the SLCO1B1 transporter.
Codeine, tramadol & CYP2D6
How you metabolize codeine/tramadol and many antidepressants via CYP2D6.
Health signals
MTHFR & folate
Your MTHFR C677T status — and why it's far less dramatic than the internet says.
Type 2 diabetes (common variants)
Two well-replicated common variants nudging type 2 diabetes risk up or down.
APOE & Alzheimer's
Your ε2/ε3/ε4 status — the strongest common genetic factor for late-onset Alzheimer's.
Traits
Caffeine metabolism
freeWhether you're a fast or slow caffeine metabolizer (CYP1A2).
Alcohol flush reaction
freeThe ALDH2 'Asian flush' variant — and its esophageal-cancer caveat.
Taste: bitter & cilantro
freeWhether cilantro tastes soapy and how strongly you taste bitter foods.
Nutrition
Lactose tolerance
Your lactase-persistence variant — can you digest dairy as an adult?
Carrier status
Cystic fibrosis carrier
The most common CF mutation (F508del) — relevant for family planning.
Sickle cell trait
Sickle cell carrier / trait status (HbS).
Hemochromatosis (iron overload)
HFE iron-overload variants C282Y & H63D — often checkable with a simple blood test.
Important. Codon is an educational tool that helps you interpret raw genetic data you already own. It is not a medical device and does not diagnose, treat, or prevent any condition. Genetic associations describe probabilities across populations, not your destiny. Always talk to a qualified clinician or genetic counselor before making any health decision.